[opensourcepharma] a open source cure for Ebola?

Thu Aug 7 22:03:25 UTC 2014

I had an interesting day today giving a talk at Boston University. They
have a former NIH-supported compound collection (
http://cmld.bu.edu/science/compoundlibraries/). If a suitable bio lab could
be found for an Ebola screen, they would be interested in contributing
their whole collection to a screening effort in the short term, open
source. This is great.

The compounds are not a repurposing library, but have interesting and
diverse chemotypes. I wonder if we can use this pledge to obtain
contributions from other labs, but before I start asking, I guess we need
to know (John M) whether there are the facilities to handle such a screen
anywhere? We're starting to talk thousands of compounds.

Gordon Conference: That's great news, John. I was just looking at their
rules yesterday. They don't do "policy" conferences, but the easy thing to
do there is to ensure the talks are on science, but to qualify they need to
be run open source, at least to some extent. It'd be really interesting to
pull that program together. Let me know (offline if you prefer) if I can
help.

Best,
M

On 7 August 2014 09:57, McKew, John (NIH/NCATS) [E] <john.mckew at nih.gov>
wrote:

> Just getting caught here as I was away at a Gordon conference this week.
>  I like the idea of crowd sourcing information using a Wiki format.  I can
> contact NIAID and see what resources they are deploying or gathered.  I
> will have to read through The papers Bernard has cited to see what was
> screened to find these compounds. I would guess nobody has screened a
> repurposing collection as large as the one we have so that might be worth
> doing.  The catch is this must be BSL4 level of containment and our
> facility can only go to BSL 2. NIAID has a faculty for BSL3 and. 4
> screening so that would be an option.  When I get back to the office I will
> look into how interested people are in this.  When people were coming down
> with CM after IT injection of steroids contaminated with fungus we were
> able to complete a screen and release data in a publication in about 3
> months from outbreak.  In that case we did not find anything new.
>
> On another note I introduced the concept of a Gordon Med Chem session on
> Open Source  Drug Discovery and Development at the planning session last
> night.  At first the idea was met with complete silence but after I sold it
> to the group I was able to gain enough enthusiasm to get this accepted into
> the next stage of decision making.  I will let everyone what I hear next.
>  As Matt mentioned at Bellagio this is primarily a very conservative group
> of med chemists so this was a nice surprise.
> John
>
> Sent from my iPhone
>
>
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-- 
MATTHEW TODD | Associate Professor
School of Chemistry | Faculty of Science

THE UNIVERSITY OF SYDNEY
Rm 519, F11 | The University of Sydney | NSW | 2006
T +61 2 9351 2180  | F +61 2 9351 3329  | M +61 415 274104
E matthew.todd at sydney.edu.au | W
http://sydney.edu.au/science/chemistry/research/todd.html | W
http://opensourcemalaria.org/

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