[opensourcepharma] a open source cure for Ebola?

Tue Aug 12 05:47:33 UTC 2014

There is this broad US patent ( http://www.google.com/patents/US20120251502
)covering ebola virus:
Reproducing Claim 1 and 2 below:
Zakir

Claims
*1*. An isolated hEbola virus comprising a nucleic acid molecule comprising
a nucleotide sequence of:
a) a nucleotide sequence set forth in SEQ ID NOS: 1 or 10;
b) a nucleotide sequence hybridizing under stringent conditions to SEQ ID
NOS: 1 or 10; or
c) a nucleotide sequence of at least 70%-99% identity to the SEQ ID NOS: 1
or 10, with the proviso that said nucleotide sequence is not SEQ ID NO: 20.
*2*. An isolated hEbola virus having Centers for Disease Control Deposit
Accession No. 200706291.
*3*. The hEbola virus of claim 1 which is killed.
*4*. The hEbola virus of claim 1 which is an attenuated hEbola virus.
*5*. The virus of claim 4 wherein at least one property of the attenuated
hEbola virus is reduced from among infectivity, replication ability,
protein synthesis ability, assembling ability or cytopathic effect.

On Fri, Aug 8, 2014 at 5:57 PM, Tomasz Sablinski <tomasz at transparencyls.com>
wrote:

> A good idea. I think we would have bigger impact if this letter is
> structured as a request for support (financial, etc) of a concrete action
> that Open Source Pharma is ready to take:
> 1/ coordinate the crowd sourced selection of suitable compound(s)
> 2/ design a clinical study protocol for testing of the above
> I am putting together a draft proposal for Open Source Pharma to consider
> Transparency Life Sciences for the execution of these crowdsourcing
> efforts; I should have something out to all of you to review in the next
> day or two.
>
> Regards,
> Tomasz
>
>
> On Fri, Aug 8, 2014 at 7:41 AM, Els Torreele <
> els.torreele at opensocietyfoundations.org> wrote:
>
>>  So Ebola was just declared a public health emergency by WHO.
>>
>> Considering the call by Jeremy Farrar (Welcome Trust), Peter Piot (London
>> School) and David Heymann (ex-WHO, now UK Health Protection Agency) to test
>> experimental treatments now (and not only on Americans) and to do so with
>> public money and leadership (not waiting for companies to develop their own
>> drugs the normal and slow way),
>> (see
>> http://online.wsj.com/articles/experimental-medicine-and-african-ebola-1407258551),
>> could we write an open letter to Farrar, Piot and Heymann and
>> proposing/demanding that this be done in an open source approach, sharing
>> all data, crowdsourcing for more data and ideas, and possibly get more and
>> more researchers on it?
>> The Welcome Trust and London School are likely supportive of an open
>> approach, and Farrar and co. could possibly be approached beforehand to
>> seek their support.
>>
>>  I'm not a good writer, but I'm sure one or several of you could develop
>> such a letter quickly, and then we can get it out early next week, before
>> WHO convenes that medical ethics expert committee to discuss the ethics of
>> the accelerated clinical research (in which data sharing could be an
>> important element)
>>
>>  What do people think?
>>
>>
>>
>>  ------------------------------
>> *From:* opensourcepharma [opensourcepharma-bounces at lists.okfn.org] on
>> behalf of Matthew Todd [mattoddchem at gmail.com]
>> *Sent:* Thursday, August 07, 2014 6:03 PM
>> *To:* opensourcepharma at lists.okfn.org
>> *Subject:* Re: [opensourcepharma] a open source cure for Ebola?
>>
>>    I had an interesting day today giving a talk at Boston University.
>> They have a former NIH-supported compound collection (
>> http://cmld.bu.edu/science/compoundlibraries/). If a suitable bio lab
>> could be found for an Ebola screen, they would be interested in
>> contributing their whole collection to a screening effort in the short
>> term, open source. This is great.
>>
>>  The compounds are not a repurposing library, but have interesting and
>> diverse chemotypes. I wonder if we can use this pledge to obtain
>> contributions from other labs, but before I start asking, I guess we need
>> to know (John M) whether there are the facilities to handle such a screen
>> anywhere? We're starting to talk thousands of compounds.
>>
>>  Gordon Conference: That's great news, John. I was just looking at their
>> rules yesterday. They don't do "policy" conferences, but the easy thing to
>> do there is to ensure the talks are on science, but to qualify they need to
>> be run open source, at least to some extent. It'd be really interesting to
>> pull that program together. Let me know (offline if you prefer) if I can
>> help.
>>
>>  Best,
>> M
>>
>>
>>
>>
>>
>> On 7 August 2014 09:57, McKew, John (NIH/NCATS) [E] <john.mckew at nih.gov>
>> wrote:
>>
>>> Just getting caught here as I was away at a Gordon conference this week.
>>>  I like the idea of crowd sourcing information using a Wiki format.  I can
>>> contact NIAID and see what resources they are deploying or gathered.  I
>>> will have to read through The papers Bernard has cited to see what was
>>> screened to find these compounds. I would guess nobody has screened a
>>> repurposing collection as large as the one we have so that might be worth
>>> doing.  The catch is this must be BSL4 level of containment and our
>>> facility can only go to BSL 2. NIAID has a faculty for BSL3 and. 4
>>> screening so that would be an option.  When I get back to the office I will
>>> look into how interested people are in this.  When people were coming down
>>> with CM after IT injection of steroids contaminated with fungus we were
>>> able to complete a screen and release data in a publication in about 3
>>> months from outbreak.  In that case we did not find anything new.
>>>
>>> On another note I introduced the concept of a Gordon Med Chem session on
>>> Open Source  Drug Discovery and Development at the planning session last
>>> night.  At first the idea was met with complete silence but after I sold it
>>> to the group I was able to gain enough enthusiasm to get this accepted into
>>> the next stage of decision making.  I will let everyone what I hear next.
>>>  As Matt mentioned at Bellagio this is primarily a very conservative group
>>> of med chemists so this was a nice surprise.
>>> John
>>>
>>> Sent from my iPhone
>>>
>>>
>>> MATTHEW TODD | Associate Professor
>>> School of Chemistry | Faculty of Science
>>>
>>> THE UNIVERSITY OF SYDNEY
>>> Rm 519, F11 | The University of Sydney | NSW | 2006
>>>  T +61 2 9351 2180<tel:%2B61%202%209351%202180>  | F +61 2 9351 3329<tel:%2B61%202%209351%203329>
>>>  | M +61 415 274104<tel:%2B61%20415%20274104>
>>> E matthew.todd at sydney.edu.au<mailto:matthew.todd at sydney.edu.au> | W
>>> http://sydney.edu.au/science/chemistry/research/todd.html | W
>>> http://opensourcemalaria.org/
>>>
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>>
>>
>>
>> --
>> MATTHEW TODD | Associate Professor
>> School of Chemistry | Faculty of Science
>>
>> THE UNIVERSITY OF SYDNEY
>> Rm 519, F11 | The University of Sydney | NSW | 2006
>> T +61 2 9351 2180  | F +61 2 9351 3329  | M +61 415 274104
>> E matthew.todd at sydney.edu.au | W
>> http://sydney.edu.au/science/chemistry/research/todd.html | W
>> http://opensourcemalaria.org/
>>
>> CRICOS 00026A
>> This email plus any attachments to it are confidential. Any unauthorised
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>> delete it and any attachments.
>>
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