[opensourcepharma] a open source cure for Ebola?

Fri Aug 8 12:27:06 UTC 2014

A good idea. I think we would have bigger impact if this letter is
structured as a request for support (financial, etc) of a concrete action
that Open Source Pharma is ready to take:
1/ coordinate the crowd sourced selection of suitable compound(s)
2/ design a clinical study protocol for testing of the above
I am putting together a draft proposal for Open Source Pharma to consider
Transparency Life Sciences for the execution of these crowdsourcing
efforts; I should have something out to all of you to review in the next
day or two.

Regards,
Tomasz

On Fri, Aug 8, 2014 at 7:41 AM, Els Torreele <
els.torreele at opensocietyfoundations.org> wrote:

>  So Ebola was just declared a public health emergency by WHO.
>
> Considering the call by Jeremy Farrar (Welcome Trust), Peter Piot (London
> School) and David Heymann (ex-WHO, now UK Health Protection Agency) to test
> experimental treatments now (and not only on Americans) and to do so with
> public money and leadership (not waiting for companies to develop their own
> drugs the normal and slow way),
> (see
> http://online.wsj.com/articles/experimental-medicine-and-african-ebola-1407258551),
> could we write an open letter to Farrar, Piot and Heymann and
> proposing/demanding that this be done in an open source approach, sharing
> all data, crowdsourcing for more data and ideas, and possibly get more and
> more researchers on it?
> The Welcome Trust and London School are likely supportive of an open
> approach, and Farrar and co. could possibly be approached beforehand to
> seek their support.
>
>  I'm not a good writer, but I'm sure one or several of you could develop
> such a letter quickly, and then we can get it out early next week, before
> WHO convenes that medical ethics expert committee to discuss the ethics of
> the accelerated clinical research (in which data sharing could be an
> important element)
>
>  What do people think?
>
>
>
>  ------------------------------
> *From:* opensourcepharma [opensourcepharma-bounces at lists.okfn.org] on
> behalf of Matthew Todd [mattoddchem at gmail.com]
> *Sent:* Thursday, August 07, 2014 6:03 PM
> *To:* opensourcepharma at lists.okfn.org
> *Subject:* Re: [opensourcepharma] a open source cure for Ebola?
>
>    I had an interesting day today giving a talk at Boston University.
> They have a former NIH-supported compound collection (
> http://cmld.bu.edu/science/compoundlibraries/). If a suitable bio lab
> could be found for an Ebola screen, they would be interested in
> contributing their whole collection to a screening effort in the short
> term, open source. This is great.
>
>  The compounds are not a repurposing library, but have interesting and
> diverse chemotypes. I wonder if we can use this pledge to obtain
> contributions from other labs, but before I start asking, I guess we need
> to know (John M) whether there are the facilities to handle such a screen
> anywhere? We're starting to talk thousands of compounds.
>
>  Gordon Conference: That's great news, John. I was just looking at their
> rules yesterday. They don't do "policy" conferences, but the easy thing to
> do there is to ensure the talks are on science, but to qualify they need to
> be run open source, at least to some extent. It'd be really interesting to
> pull that program together. Let me know (offline if you prefer) if I can
> help.
>
>  Best,
> M
>
>
>
>
>
> On 7 August 2014 09:57, McKew, John (NIH/NCATS) [E] <john.mckew at nih.gov>
> wrote:
>
>> Just getting caught here as I was away at a Gordon conference this week.
>>  I like the idea of crowd sourcing information using a Wiki format.  I can
>> contact NIAID and see what resources they are deploying or gathered.  I
>> will have to read through The papers Bernard has cited to see what was
>> screened to find these compounds. I would guess nobody has screened a
>> repurposing collection as large as the one we have so that might be worth
>> doing.  The catch is this must be BSL4 level of containment and our
>> facility can only go to BSL 2. NIAID has a faculty for BSL3 and. 4
>> screening so that would be an option.  When I get back to the office I will
>> look into how interested people are in this.  When people were coming down
>> with CM after IT injection of steroids contaminated with fungus we were
>> able to complete a screen and release data in a publication in about 3
>> months from outbreak.  In that case we did not find anything new.
>>
>> On another note I introduced the concept of a Gordon Med Chem session on
>> Open Source  Drug Discovery and Development at the planning session last
>> night.  At first the idea was met with complete silence but after I sold it
>> to the group I was able to gain enough enthusiasm to get this accepted into
>> the next stage of decision making.  I will let everyone what I hear next.
>>  As Matt mentioned at Bellagio this is primarily a very conservative group
>> of med chemists so this was a nice surprise.
>> John
>>
>> Sent from my iPhone
>>
>>
>> MATTHEW TODD | Associate Professor
>> School of Chemistry | Faculty of Science
>>
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>
> --
> MATTHEW TODD | Associate Professor
> School of Chemistry | Faculty of Science
>
> THE UNIVERSITY OF SYDNEY
> Rm 519, F11 | The University of Sydney | NSW | 2006
> T +61 2 9351 2180  | F +61 2 9351 3329  | M +61 415 274104
> E matthew.todd at sydney.edu.au | W
> http://sydney.edu.au/science/chemistry/research/todd.html | W
> http://opensourcemalaria.org/
>
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